Wilkes Skin Secretions of Caecilian Siphonops Paulensis
Answer next questions:
1.The effects of the skin secretions of the caecilian (legless salamander) Siphonops paulensis are two-fold. First it is a hemolytic toxin; that is it lyses RBC. What effects would this toxin have on a human based on this side-effect? Include effects related to the recycling of red blood cells.
2.Secondly the skin secretion is cardiotoxic. Part of the effect of lysing RBC’s is that there is an increase of K+ in the blood which especially has an effect on the heart (I’ll bet you didn’t think of that in question #1).The result of this is diastolic arrest. Explain how the change of K+ concentration could lead to diastolic arrest. How could you prevent this?
The Taiwan habu is a very venomous snake whose venom contains proteases that cleave angiotensin I and releases bradykinin in the plasma. What would be the direct and indirect results to a human who has been bitten by this snake?